Free Radical-scavenging and Antimicrobial Activities of Schisandrin B from Schisandra chinensis

doi:10.7506/spkx1002-6630-201105017

FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (5 ): 79-82.doi: 10.7506/spkx1002-6630-201105017

• Basic Research • Previous Articles Next Articles

Free Radical-scavenging and Antimicrobial Activities of Schisandrin B from Schisandra chinensis

LI Bin，MENG Xian-jun*，XUE Xue，WU Qian，LI Yuan-su，WANG Yan-qun

College of Food Science, Shenyang Agricultural University, Shenyang 110866, China

Received:2010-05-24 Revised:2011-01-22 Online:2011-03-15 Published:2011-03-03
Contact: MENG Xian-jun E-mail:mengxjsy@126.com

Abstract

Abstract: Schisandrin B obtained from the fruits of Schisandra chinensis by supercritical carbon dioxide extraction and subsequent preparative HPLC separation was tested for its free radical-scavenging and antimicrobial activities in vitro. The results showed that Schisandra chinensis-derived schisandrin B had higher hydroxyl radical scavenging effect (IC50 = 0.2 mg/mL) but lower superoxide anion radical scavenging effect (IC50 = 0.24 mg/mL) when compared with vitamin C at the same concentrations. The compound could inhibit Staphylococcus aureus, Candida albicans, Salmonella, E.coli and Bacillus subtilis, especially against Candida albicans and Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 0.25 mg/mL. However, no obvious inhibitory effect on Rhizopus, Aspergillus niger or Nanyang yeast was observed.

Key words: Schisandra chinensis (Turcz.) Baill, schisandrin B, free radical-scavenging activity, antimicrobial activity

CLC Number:

TS201.2

LI Bin，MENG Xian-jun*，XUE Xue，WU Qian，LI Yuan-su，WANG Yan-qun. Free Radical-scavenging and Antimicrobial Activities of Schisandrin B from Schisandra chinensis[J]. FOOD SCIENCE, 2011, 32(5 ): 79-82.

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Free Radical-scavenging and Antimicrobial Activities of Schisandrin B from Schisandra chinensis

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